Abcam, ab120843, Dorsomorphin (Compound C), AMP-kinase inhibitor

Size: 5mg / 10mg / 50mg
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (K i = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
Key facts
CAS number:866405-64-3,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:399.5 Da,
Molecular formula:C24H25N5O,
PubChem:11524144,
Nature:Synthetic,
Solubility:Soluble in DMSO to 10 mM,
Biochemical name:Dorsomorphin,
Biological description:Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821),
Canonical smiles:C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3,
InChi:InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2,
InChiKey:XHBVYDAKJHETMP-UHFFFAOYSA-N,
IUPAC Name:6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months