Abcam, ab120859, PP 1, Src family tyrosine kinase inhibitor

Size: 10mg
MW 281.36 Da, Purity >98%. Potent Src family tyrosine kinase inhibitor. Inhibits a multitude of kinases (IC 50 values are 0.05 (LCK), 0.52 (CSK), 0.64 (p38α) and 1.06 (CK1δ) μM). Inhibits Bcr-Abl kinase and induces apoptosis.
Key facts
CAS number:172889-26-8,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:281.36 Da,
Molecular formula:C16H19N5,
PubChem:1400,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mMSoluble in ethanol to 10 mM,
Biochemical name:1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine,
Biological description:Potent Src family tyrosine kinase inhibitor. Inhibits a multitude of kinases (IC50 values are 0.05 (LCK), 0.52 (CSK), 0.64 (p38α) and 1.06 (CK1δ) μM). Inhibits Bcr-Abl kinase and induces apoptosis.,
Canonical smiles:CC1=CC=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)(C)C,
InChi:InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19),
InChiKey:ZVPDNRVYHLRXLX-UHFFFAOYSA-N,
IUPAC Name:1-tert-butyl-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The biological targets p38 mTOR Src RIP2 CSNK1D Ret VEGF Receptor 2 c-Kit Fyn EGFR Lck TDP1 ABL1 PDGFR alpha + beta TIE2 and Yes1 comprise a group of proteins and kinases with significant mechanical functions in cellular processes. These targets play roles in signal transduction growth regulation and cellular differentiation. They have diverse alternate names; for example VEGF Receptor 2 is also known as KDR or Flk-1 while c-Kit is referred to as CD117. Many of these proteins are expressed in various tissues with high concentrations often found in tumor cells or critical organ systems. The masses of these proteins vary with some like mTOR being around 289 kDa reflecting their complex structures.
Biological function summary
These proteins have key roles in cellular communication and homeostasis often by activating or inhibiting signaling pathways. For instance mTOR (mechanistic target of rapamycin) is a central component of the mTOR complex which regulates cell growth and metabolism. Src (proto-oncogene tyrosine-protein kinase Src) influences cell division and adhesion. VEGF Receptor 2 through angiogenic signaling modulates blood vessel formation. Their presence within multiprotein complexes often facilitates or modulates downstream signaling effectively integrating external stimuli with cellular responses.
Pathways
A significant number of these proteins are involved in the PI3K/AKT/mTOR and MAPK/ERK pathways essential for controlling cell proliferation survival and apoptosis. For example mTOR interacts closely with AKT and PI3K regulating cell growth and survival. Similarly the MAPK pathway involving targets like Src and p38 contributes to cellular responses to stress and growth factors. These pathways highlight intricate relationships among these proteins creating a network of interactions that affect numerous cell functions.
These proteins show strong links to cancer and inflammatory conditions. Abnormal activity of mTOR VEGF Receptor 2 and EGFR is frequently associated with various cancers where they contribute to uncontrolled cell growth and resistance to apoptosis. Src and Lck have connections to autoimmune diseases with dysregulated signaling leading to chronic inflammation and tissue damage. Through these pathological contexts the roles of these proteins in disease development are further emphasized impacting drug targeting strategies and therapeutic interventions.