Abcam, ab120960, Indirubin, cyclin-dependent kinase and GSK-3 beta inhibitor

Size: 5mg / 25mg
MW 262.26 Da, Purity >98%. Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor (IC 50 values are 5.5 μM at CDK5, 9 μM at CDK1 and 600 nM at GSK-3β). Antimitotic and antitumoral properties induces cell cycle arrest, inhibits cell proliferation AMPK, LCK and SGK. Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, an over-active process in Alzheimer disease states.
Key facts
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:262.26 Da,
Molecular formula:C16H10N2O2,
PubChem:5359405,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 100 mM,
Biochemical name:CID 5359405,
Biological description:Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor (IC50 values are 5.5 μM at CDK5, 9 μM at CDK1 and 600 nM at GSK-3β). Antimitotic and antitumoral properties induces cell cycle arrest, inhibits cell proliferation AMPK, LCK and SGK. Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, an over-active process in Alzheimer disease states.,
Canonical smiles:C1=CC=C2C(=C1)C(=C3C(=O)C4=CC=CC=C4N3)C(=O)N2,
Isomeric smiles:C1=CC=C2C(=C1)/C(=C\3/C(=O)C4=CC=CC=C4N3)/C(=O)N2,
InChi:InChI=1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13+,
InChiKey:CRDNMYFJWFXOCH-BUHFOSPRSA-N,
IUPAC Name:(3E)-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions