Abcam, ab120993, ZIP, protein kinase Czeta (PKC-zeta) inhibitor

Size: 1mg
MW 1928.4 g/mol, Purity >94%. Novel, cell-permeable PKCζ inhibitor, a constitutively active, atypical PKM isozyme. Efficacious in in vitro and in vivo models of synaptic plasticity (IC 50 = 1 - 2.5 μM).
Key facts
CAS number:863987-12-6,
Purity:>94%,
Form:SolidSee storage information,
Molecular weight:1928.4 g/mol,
Nature:Synthetic,
Solubility:Soluble in water,
Biological description:Novel, cell-permeable PKCζ inhibitor, a constitutively active, atypical PKM isozyme. Efficacious in in vitro and in vivo models of synaptic plasticity (IC50 = 1 - 2.5 μM).

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PKC zeta also known as Protein Kinase C zeta is a member of the atypical protein kinase C family. This enzyme plays an important role in various cellular processes. PKC zeta has a molecular mass of about 55 kDa and is expressed in many tissues including brain and immune cells. Unlike conventional PKC enzymes PKC zeta does not respond to calcium or diacylglycerol which influences its unique regulatory roles.
Biological function summary
PKC zeta participates in regulating cell proliferation survival and differentiation. It often functions as part of signaling complexes that include other proteins like PDK1 and is involved in transducing signals from cell surface receptors to the nucleus. Its activity influences cellular responses to hormones growth factors and cytokines contributing to diverse cellular events.
Pathways
PKC zeta plays a critical role in the NF-kappaB and PI3K/Akt signaling pathways. In the NF-kappaB pathway PKC zeta helps in the activation of this transcription factor affecting genes related to inflammation and immune response. In the PI3K/Akt pathway it is involved in cell growth and survival interacting with kinases such as Akt and PDK1 which further modulate downstream effectors.
PKC zeta has associations with cancer and insulin resistance-related conditions. In cancer dysregulation of PKC zeta can lead to unchecked cellular proliferation due to its involvement in survival pathways and it often interacts with oncogenic proteins like Akt. In insulin resistance PKC zeta misregulation impacts glucose metabolism highlighting its role in diabetes-related pathways alongside insulin receptor substrates.