Abcam, ab121109, Anti-TECPR2 antibody

Size: 100µL
Rabbit Polyclonal TECPR2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TECPR2 aa 1250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TECPR2 aa 1250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O15040

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TECPR2 also known as Tectonin Beta-Propeller Repeat Containing 2 is a protein with a mass of approximately 150 kDa. It plays a significant role in autophagy which the body uses to clean out damaged cells and regenerate new ones. Researchers have found TECPR2 expressed highly in the brain and muscle tissues suggesting its integral role in nervous system health and muscular functions. The technical aspects of TECPR2 include its involvement in cellular mechanisms that help maintain cellular homeostasis.
Biological function summary
The protein TECPR2 assists in the regulation of autophagosome maturation a critical step in the autophagy process. It is a part of a complex that mediates efficient autophagic flux interacting with other autophagic machinery proteins to ensure correct progression and completion of autophagy. TECPR2 contributes to cellular waste disposal by ensuring damaged organelle degradation maintaining cellular integrity and function through this mechanism.
Pathways
The protein TECPR2 participates mainly in the autophagy pathway where it works closely with LC3 and p62 proteins. This pathway is important for removing damaged components and recycling cellular resources. TECPR2 helps regulate these processes directly linking to how cell responds to stress conditions and nutrient deficiency. The balance maintained by TECPR2 in these pathways is key for overall cellular health and its failure can lead to detrimental outcomes.
Mutations or dysfunctions in TECPR2 have been associated with neurodegenerative diseases such as hereditary spastic paraplegia. TECPR2 mutations disrupt normal autophagic balance and can lead to the accumulation of damaged proteins that harm neural cells. Additionally research indicates potential links to muscle wasting disorders due to its critical role in muscle tissue homeostasis. Connections between dysfunctional TECPR2 and abnormal protein aggregates often overlap with proteins involved in neurodegeneration emphasizing its healthcare importance.