Abcam, ab121173, Anti-ZNF589 antibody

Size: 100µL
Rabbit Polyclonal ZNF589 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF589 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF589 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q86UQ0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF589 also known as Zinc Finger Protein 589 is a protein coding gene with an estimated molecular weight of approximately 73 kDa. This target functions as a transcription factor by using its C2H2-type zinc finger domains to bind specific DNA sequences. It plays a regulatory role in gene expression. ZNF589 shows expression in hematopoietic cells and evidence indicates its presence in other cell types of the immune system as well.
Biological function summary
Zinc finger proteins like ZNF589 regulate many genes involved in cell differentiation and proliferation. ZNF589 is involved in the control of hematopoietic stem and progenitor cells. It may be part of larger protein-DNA complexes that modulate transcriptional programs essential for maintaining stem cell properties. Such functions ensure proper balance and renewal of blood cells.
Pathways
The actions of ZNF589 involve specific signaling cascades such as hematopoiesis and immune response pathways. This protein interacts with others like GATA-2 which is known to be important in hematopoietic stem cell regulation and with components of the Notch signaling pathway facilitating communication between stem cells and their microenvironment.
Disturbances in ZNF589 activity have been linked to hematological disorders including certain leukemias. Aberrant expression or mutation in ZNF589 may contribute to unregulated cell proliferation and differentiation leading to malignancies. Additionally its interaction with proteins such as RUNX1 which is involved in acute myeloid leukemia provides insight into the protein's role in these conditions emphasizing its significance in maintaining normal blood cell development and function.