Abcam, ab121215, Anti-TPPP2 antibody

Size: 100µL
Rabbit Polyclonal TPPP2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TPPP2 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TPPP2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.P59282

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TPPP2 also known as tubulin polymerization-promoting protein family member 2 is an important protein in the cellular microtubule network. It facilitates microtubule dynamics by promoting polymerization impacting cellular structure and mechanics. TPPP2 has a mass of approximately 22 kDa. Expression of TPPP2 is observed in various tissues though it is notably present in the nervous system where it plays a pivotal role in maintaining neuron architecture.
Biological function summary
This protein impacts cellular processes beyond microtubule stabilization. TPPP2 engages with other cytoskeletal proteins contributing to cell shape and motility. It does not typically form large protein complexes but interacts directly with tubulin forming a functional axis that modulates cytoskeleton behavior. The protein’s involvement is essential for processes like mitosis and intracellular transport.
Pathways
The participation of TPPP2 in the microtubule-related pathways underpins its functional significance. It plays a role in the cytoskeleton organization and cell cycle regulation. The MAPK signaling pathway an important regulator of cellular responses to various stimuli shows connections to TPPP2. This protein has relationships with other key microtubule-associated proteins such as tau which also contribute to the dynamic regulation of microtubule networks.
TPPP2 implicates itself in neurodegenerative diseases like Parkinson’s disease. Altered expression or mutation of TPPP2 can affect microtubule stability influencing disease progression. The protein’s connection with tau is particularly relevant in Alzheimer's disease where tau dysfunction is a significant pathological feature. Studying TPPP2 provides insight into the molecular mechanisms underpinning these disorders and potential therapeutic targets.