Abcam, ab121235, Anti-CCDC88C antibody

Size: 100µL
Rabbit Polyclonal CCDC88C antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CCDC88C aa 1550-1700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CCDC88C aa 1550-1700. The exact immunogen used to generate this antibody is proprietary information.Q9P219

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The coiled-coil domain-containing protein 88C also known as CCDC88C or HDApL is a scaffold protein involved in intracellular signaling pathways. This protein has a molecular mass of approximately 195 kDa and is ubiquitously expressed in human tissues particularly in the brain. CCDC88C acts as a regulator of various cellular functions and possesses the ability to interact with multiple other proteins within the cell.
Biological function summary
CCDC88C facilitates organization and signaling within cellular structures. It is a part of the multiprotein complexes that regulate the cytoskeleton and influence cell polarity and migration. By interacting with other proteins CCDC88C ensures correct positioning and function of essential cellular components which is important for neurodevelopment and cellular integrity.
Pathways
CCDC88C plays a significant role in the Wnt signaling and the PI3K/Akt pathways. These pathways are vital for cell growth differentiation and survival. CCDC88C interacts with the Dishevelled (Dvl) proteins and beta-catenin within the Wnt pathway while also connecting with phosphoinositide 3-kinase (PI3K) for signaling transduction in the PI3K/Akt pathway. These interactions highlight its importance in multiple signaling cascades.
CCDC88C is linked to neurodevelopmental disorders and glioma. Mutations in CCDC88C can lead to conditions such as Intellectual Disability and Lissencephaly. In glioma it may interact with proteins such as EGFR (Epidermal Growth Factor Receptor) influencing tumor progression and response to treatments. Understanding CCDC88C's involvement in these conditions may guide therapeutic strategies.