Abcam, ab121248, Anti-PDZK1 antibody

Size: 100µL
Rabbit Polyclonal PDZK1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDZK1 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PDZK1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q5T2W1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PDZK1 protein also known as Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a scaffolding protein with a molecular weight of about 70 kDa. This protein contains multiple PDZ domains which facilitate interactions with various transmembrane and cytosolic partners. PDZK1 is expressed in several tissues notably in the liver kidney and small intestine where it plays a role in membrane protein localization and ion transport regulation.
Biological function summary
This multi-domain protein binds and organizes specific signaling complexes by interacting with different cellular components. PDZK1 often acts as an adapter to control the trafficking and function of ion transporters and other membrane proteins within epithelial cells. It forms complexes with proteins such as CFTR (cystic fibrosis transmembrane conductance regulator) to regulate ion channels important for epithelial function.
Pathways
PDZK1 plays an active role in regulating the PDZ protein-mediated signaling cascade and also influences the cAMP-mediated cellular response pathway. PDZK1 modulates the activity of ion transporters by interacting with proteins like NHERF1 and NHERF2. These relationships assist in cell signaling transduction related to ion homeostasis and transport regulation.
Mutations or altered expression of PDZK1 have associations with disorders like cystic fibrosis and renal diseases. PDZK1 directly interacts with CFTR implicating it in cystic fibrosis when regulatory processes are dysfunctional. Additionally altered PDZK1 expressions can impact sodium and phosphate transporter regulation linking it to renal dysfunctions.