Abcam, ab121254, Anti-USP42 antibody

Size: 100µL
Rabbit Polyclonal USP42 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human USP42 aa 450-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human USP42 aa 450-600. The exact immunogen used to generate this antibody is proprietary information.Q9H9J4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP42 also known as Ubiquitin-specific peptidase 42 is part of the ubiquitin-proteasome system. USP42 specifically removes ubiquitin molecules from specific protein substrates. This action involves deubiquitination a process that regulates protein degradation. The molecular weight of USP42 is approximately 150 kDa. In terms of expression USP42 is found in various tissues including the liver brain and kidneys indicating it has a broad role across different systems of the body.
Biological function summary
The function of USP42 is important in gene regulation and cell cycle control. By controlling protein stability it influences transcriptional activity and cellular responses to stress. USP42 associates with the p53 protein stabilizing it and enhancing its tumor suppressor function. Additionally it forms part of larger protein complexes that coordinate DNA damage responses. Through these interactions USP42 supports cellular health by ensuring proper repair and replication of DNA.
Pathways
In these pathways USP42 plays a part in modulating ubiquitin ligases and deubiquitinases activities maintaining protein homeostasis. The protein acts in concert with others like Mdm2 and p53 important for cellular stress responses and apoptosis. These pathways highlight the impact of USP42 in balancing cell survival and programmed cell death mechanisms.
Altered USP42 expression or function has links to tumorigenesis due to its interaction with proteins such as p53. Dysregulation in this pathway may contribute to cancer proliferation. In neurodegenerative conditions abnormal protein aggregation occurs if ubiquitin-proteasome function is impaired connecting to USP42's role in maintaining protein quality control. The protein's dysfunction can therefore influence disease progression by failing to regulate protein turnover properly.