Abcam, ab121366, Anti-MRPL52 antibody

Size: 100µL
Rabbit Polyclonal MRPL52 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MRPL52 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MRPL52 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q86TS9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPL52 known as 39S ribosomal protein L52 is vital for mitochondrial protein synthesis. This small protein has a mass of about 16 kilodaltons. Researchers find its expression mainly within the mitochondria where it acts as a component of the large subunit of mitochondrial ribosomes. Through its contribution to the structural and functional integrity of ribosomes MRPL52 supports the complex process of mitochondrial translation.
Biological function summary
MRPL52 aids in the synthesis of proteins encoded by mitochondrial DNA. Integral to the mitochondrial ribosome's large subunit it is important for translation and maintaining mitochondrial function. MRPL52 works in close association with other ribosomal proteins to ensure proper assembly and translation efficacy of the ribosome. Its role critically influences mitochondrial biogenesis and cellular energy production.
Pathways
MRPL52 contributes to pathways involved in mitochondrial biogenesis and oxidative phosphorylation. Its function links closely to the pathway that governs mitochondrial translation collaborating with other ribosomal proteins and translation factors. Through these pathways MRPL52 supports cellular energy metabolism and helps in the production of essential proteins for mitochondrial respiration. It interacts functionally with other mitochondrial translation machinery components amplifying its significance.
Researchers have associated MRPL52 with mitochondrial disorders including mitochondrial myopathy and mitochondrial encephalopathy. The disruption in its normal function can lead to defects in mitochondrial protein synthesis diminishing cellular energy supply. MRPL52 shares ties with disorders through interactions with other mitochondrial proteins involved in translation and maintenance of mitochondrial health. Understanding these interactions offers insight into therapeutic opportunities for mitochondrial diseases.