Abcam, ab121425, Anti-OPALIN antibody

Size: 100µL
Rabbit Polyclonal OPALIN antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OPALIN aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human OPALIN aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96PE5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OPALIN also known as Opalin sialomucin or oligodendrocytic myelin paranodal and inner loop protein is a small transmembrane protein with a molecular mass of approximately 11 kDa. Researchers discovered OPALIN in the myelin of the central nervous system specifically expressed in oligodendrocytes. OPALIN functions in cell signaling and is essential for myelin sheath integrity which ensures proper nerve impulse conduction.
Biological function summary
OPALIN is important for oligodendrocyte differentiation and myelination processes critical for the development and maintenance of the central nervous system. OPALIN integrates within the myelin sheath as part of a complex membrane structure assisting in the formation and stabilization of myelin. Its presence is integral for proper myelin development and long-term stability contributing to neuronal function and communication.
Pathways
OPALIN interacts with the oligodendrogenesis pathway which oversees the formation of myelinating cells. In this pathway proteins like Myelin Basic Protein (MBP) and Proteolipid Protein (PLP) are related to OPALIN as they also play pivotal roles in myelin sheath formation and maintenance. OPALIN’s interaction in this context makes it an essential component in ensuring effective myelin repair and function within neural pathways.
OPALIN holds significance for multiple sclerosis (MS) and leukodystrophies. These conditions are characterized by the degeneration or dysfunction of myelin and improper expression or functioning of OPALIN could influence disease progression. In these disorders altered interactions between OPALIN and other myelin-associated proteins like MBP could contribute to pathological outcomes and highlights the importance of maintaining proper OPALIN function for neural health.