Abcam, ab121431, Anti-TMEM143 antibody

Size: 100µL
Rabbit Polyclonal TMEM143 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM143 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM143 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q96AN5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM143 also known as Transmembrane Protein 143 is a protein located within the membrane structures of cells. It has a molecular mass of approximately 24 kDa. Researchers have found TMEM143 expression in various tissues with high levels noted in the heart and skeletal muscles. This protein spans the membrane indicating its role in transporting ions or other molecules across cellular barriers.
Biological function summary
TMEM143 participates in the regulation of calcium ion homeostasis within muscle cells. Its function is essential for maintaining correct calcium levels which is necessary for proper muscle contraction and relaxation. TMEM143 does not currently appear to be part of any larger known protein complexes. Nonetheless it interacts with cellular components to influence muscle physiology significantly.
Pathways
TMEM143 plays a role in the calcium signaling pathway critical for muscle function and cellular signaling. This pathway collaborates with proteins such as the ryanodine receptor which controls the release of calcium ions from the sarcoplasmic reticulum. TMEM143's involvement ensures that muscle cells respond appropriately to signals demanding contraction and energy consumption.
Researchers associate TMEM143 with conditions such as cardiomyopathy and certain muscular dystrophies. These disorders affect muscle function and strength attributable to disrupted calcium homeostasis. TMEM143's interaction with ryanodine receptors suggests its role in the pathological progression of these conditions offering potential areas for therapeutic targeting to mitigate disease impacts.