Abcam, ab121434, Anti-TMEM223 antibody

Size: 100µL
Rabbit Polyclonal TMEM223 antibody. Suitable for ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM223 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM223 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.A0PJW6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM223 also known as Transmembrane Protein 223 is a protein that resides within the membrane and consists of 236 amino acids having an approximate molecular mass of 27 kDa. Researchers have found that TMEM223 is expressed mainly in the brain with lower expression levels detected in tissues like the kidney and liver. The protein is localized in the membrane compartments of cells where it may be involved in cellular processes that require transmembrane activity although its precise mechanical actions remain under investigation.
Biological function summary
The protein plays a role in maintaining cellular homeostasis. It might participate in cellular signaling pathways or interact with other membrane proteins although it is not definitively known to be part of any specific protein complex. Some studies suggest that TMEM223 might influence ion transport or facilitate communication across the cell membrane impacting cellular response to environmental changes or stress.
Pathways
The protein's function appears to connect to neurotransmission and cellular signaling networks. TMEM223 might interact with other proteins like synaptic vesicle-associated proteins within the neurotransmission process facilitating signal propagation in the nervous system. For cellular signaling it potentially engages with pathways involving receptor tyrosine kinases where it could modulate downstream signaling cascades and affect cellular responses to external stimuli.
Research indicates potential implications for TMEM223 in neurodegenerative diseases such as Alzheimer's disease. This connection arises through its probable interaction with proteins like amyloid precursor protein (APP) or tau which play roles in the disease's pathology. Moreover TMEM223 might be involved in kidney pathologies given its expression in renal tissues possibly through its association with proteins implicated in renal function or dysfunction.