Abcam, ab121493, Anti-TMEM132C antibody

Size: 100µL
Rabbit Polyclonal TMEM132C antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM132C aa 750-950.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM132C aa 750-950. The exact immunogen used to generate this antibody is proprietary information.Q8N3T6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM132C or Transmembrane Protein 132C is a protein with a molecular mass of approximately 120 kDa. It is part of the TMEM family and is known for its role as a membrane protein. TMEM132C expresses in various tissues with a notable presence in the brain particularly within the cortex and hippocampus regions. This distribution suggests potential involvement in neurological processes.
Biological function summary
TMEM132C contributes to cell adhesion and signal transduction. It interacts with other proteins to maintain cellular communication. The protein is not known to be part of a specific complex but it contributes to cellular activities essential for proper neural function. Its mechanical properties might influence neural connectivity and plasticity important factors in the central nervous system's response to environmental stimuli.
Pathways
Connections between TMEM132C and the PI3K/AKT signaling pathway have been observed. This pathway plays an important part in regulating cellular processes such as growth survival and metabolism. TMEM132C also interacts with the NF-κB pathway that influences inflammation and immune response. By engaging with proteins like AKT and NF-κB TMEM132C plays a significant role in ensuring proper signaling and adaptability within cellular systems.
TMEM132C mutations and expression changes have been linked to anxiety disorders and depression. Studies highlight its connection to the pathophysiology of mental health conditions as variations in this protein can affect neural plasticity and signal transmission. Additionally TMEM132C exhibits interrelations with other proteins such as GABA receptors in the context of these disorders influencing how neurotransmitter signals are processed and modulated within the brain.