Abcam, ab121537, Anti-SLFN5 antibody

Size: 100µL
Rabbit Polyclonal SLFN5 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SLFN5 aa 50-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLFN5 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.Q08AF3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLFN5 also known as Schlafen family member 5 is a protein with a mass of approximately 104 kDa. It functions as an ATP/GTP-binding protein which plays a role in RNA processing and decay. SLFN5 is localized predominantly in the cytoplasm and nucleus suggesting versatility in its functions. It is expressed in various tissues including immune and epithelial cells indicating its involvement in broad physiological processes.
Biological function summary
SLFN5 plays a role in modulating immune cell responses and influencing cell proliferation. It acts as a regulatory element that affects the innate immune response possibly through interactions with nucleic acids. At a molecular level it associates with proteins involved in cell cycle regulation and differentiation therefore integrating into larger protein complexes that impact cell fate decisions.
Pathways
SLFN5 is an integral part of the immune response and cell cycle regulation pathways. It interacts with other Schlafen family proteins as well as signal transducers like STAT1 to execute its regulatory functions. SLFN5's presence in these pathways indicates its role in maintaining cellular homeostasis and modulating responses to external stimuli such as viral infections.
SLFN5 associates with cancer and viral infections such as hepatitis C. It has shown expression changes in various cancer types including melanoma where it may influence tumor cell proliferation and immune evasion. SLFN5's interaction with proteins like STAT1 and other immune modulators suggests its involvement in the pathology and potentially highlights it as a target for therapeutic intervention.