Abcam, ab121639, Anti-MMRN2 antibody

Size: 100µL
Rabbit Polyclonal MMRN2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MMRN2 aa 300-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MMRN2 aa 300-500. The exact immunogen used to generate this antibody is proprietary information.Q9H8L6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MMRN2 also known as Multimerin 2 is a large extracellular matrix protein with a mass of approximately 122 kDa. It is encoded by the MMRN2 gene. MMRN2 expresses itself in a variety of tissues with higher levels in the vascular endothelium and the placenta. It shows presence in blood vessels and interacts with other endothelial components. This protein binds to cell surfaces and extracellular matrix components suggesting its role in vascular biology.
Biological function summary
Multimerin 2 functions in modulating the extracellular matrix organization. It does this by interacting with various cellular surface receptors and glycoproteins potentially through multimeric structures. MMRN2 engages in producing an environment that supports cell adhesion and migration which makes it important for tissue repair and integrity. It is not generally a part of a larger complex but rather exerts influence through its interactions with several proteins and matrix molecules.
Pathways
Multimerin 2 participates in angiogenesis and blood coagulation processes. It influences the formation and remodeling of blood vessels playing a significant role in the angiogenic pathways. MMRN2 indirectly contributes to the regulation of thrombin an important enzyme in the coagulation cascade and interacts with proteins like fibrinogen and von Willebrand factor within these pathways. These interactions help maintain vascular stability and regulate blood clotting.
Multimerin 2 has been associated with cancer progression and cardiovascular diseases. Elevated levels of MMRN2 have been linked to tumor growth due to its role in promoting angiogenesis. It relates to von Willebrand factor and thrombin in the context of cardiovascular disorders contributing to irregularities in blood flow and clot formation. Understanding these connections could lead to new therapeutic strategies targeting MMRN2 to manage and treat such conditions.