Abcam, ab121718, Anti-MSL1 antibody

Size: 100µL
Rabbit Polyclonal MSL1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MSL1 aa 200-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MSL1 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.Q68DK7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MSL1 or Male-Specific Lethal 1 functions mechanically as an important component of the MSL complex that engages in gene regulation activities. It has a molecular mass of approximately 62 kDa. MSL1 expresses in diverse tissues including the brain liver and muscle. It plays a critical role in dosage compensation contributing to equalizing gene expression levels between sexes in species like Drosophila.
Biological function summary
MSL1 participates in the assembly of the MSL complex. This multi-protein complex facilitates histone H4 lysine 16 acetylation which activates transcription. MSL1 specifically assists in recruiting the acetyltransferase MOF to target sites on the X chromosome. The expression level and activity of MSL1 are tightly regulated to ensure proper chromosomal balance in the organism. Its activity is not limited to dosage compensation but also influences other chromatin remodeling processes.
Pathways
MSL1 plays significant roles in chromatin modification pathways participating in transcriptional regulation actively. The protein aligns closely with MOF in these pathways forming a duo that heavily influences acetylation across chromatin landscapes. In addition to histone modification MSL1 connections extend to gene expression pathways responding to various cellular stimuli interfacing with proteins like MSL2 and MSL3 to regulate gene activation machinery.
MSL1 has associations with certain cancers including breast cancer and leukemia. The protein's dysregulation can skew chromatin remodeling leading to abnormal gene expression profiles commonly seen in tumorigenesis. MSL1 partners with other proteins like MOF impacting the transcriptional regulatory networks often targeted in cancer therapies. Understanding MSL1's role allows for targeted approaches in developing therapeutic strategies for these diseases.