Abcam, ab121737, Anti-SLFN13 antibody

Size: 100µL
Rabbit Polyclonal SLFN13 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLFN13 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLFN13 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q68D06

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLFN13 also known as Schlafen family member 13 is a protein involved in various cellular processes. It has a molecular mass of about 86 kDa. This protein is mainly expressed in immune-related tissues including the spleen and lymph nodes. Mechanistically SLFN13 contains a unique SLFN domain and an ATP binding site suggesting a role in nucleic acid metabolism and possibly in regulating other processes within the cell.
Biological function summary
SLFN13 influences immune cell function and development. It is not part of a larger protein complex but it does interact with other cellular machinery involved in immune responses. Studies show SLFN13 modulates T-cell proliferation and influences inflammatory signaling pathways. This highlights its significance in coordinating immune responses during infections and immune challenges.
Pathways
SLFN13 takes part in the immune response signaling and inflammatory pathways. It interacts specifically in pathways like the interferon response and Th1 differentiation. Through these pathways SLFN13 connects with proteins such as STAT1 and IRF9 which play roles in activating the immune response when an organism faces pathogens.
SLFN13 holds relevance in autoimmune disorders and infectious diseases. Its altered expression levels can link to conditions such as systemic lupus erythematosus and viral infections where immune function is compromised or hyperactive. In these contexts SLFN13 influences or gets influenced by proteins like IFN-α and TNF-α which are critical in immune system regulation and chronic inflammation settings.