Abcam, ab121784, Anti-GIGYF1 antibody

Size: 100µL
Rabbit Polyclonal GIGYF1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GIGYF1 aa 400-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GIGYF1 aa 400-500. The exact immunogen used to generate this antibody is proprietary information.O75420

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GIGYF1 also known as Grb10 Interacting GYF Protein 1 is a protein involved in cellular signaling. The protein has a mass of approximately 140 kDa. It is expressed widely in various tissues with significant expression in the brain pancreas and testis. GIGYF1 contains the GYF domain which enables interaction with other proteins involved in signal transduction.
Biological function summary
GIGYF1 interacts with the insulin receptor pathway playing a role in growth factor signaling. It forms a complex with Grb10 working together to affect cellular responses to insulin. This protein is essential for growth regulation and metabolic processes offering a bridge between external signals and internal cellular mechanisms. GIGYF1's interaction with insulin signaling makes it a significant player in maintaining energy homeostasis.
Pathways
GIGYF1 impacts both the insulin and IGF signaling pathways which are important for regulating metabolism and growth. It interacts closely with proteins such as mTOR and Akt influencing cell survival and growth processes. GIGYF1 acts as a mediator in transmitting signals from these pathways affecting overall cellular responses to insulin.
GIGYF1 has been linked to diabetes and some forms of cancer. Alterations in GIGYF1 expression may disrupt normal insulin signaling contributing to insulin resistance associated with diabetes. In cancer its interaction with mTOR could influence cancer cell growth and survival given mTOR’s role in cell proliferation and metabolism. Understanding GIGYF1's role in these disorders could provide insights into disease mechanisms and potential therapeutic targets.