Abcam, ab121788, Anti-LMCD1 antibody

Size: 100µL
Rabbit Polyclonal LMCD1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LMCD1 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LMCD1 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q9NZU5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LMCD1 also known as LIM and cysteine-rich domains protein 1 is a protein that plays several roles at the cell level. This protein has a mass of approximately 39 kDa. LMCD1 is expressed in various tissues in the body including the heart and liver. It contains LIM domains which are important for protein-protein interactions and cysteine-rich domains which contribute to its function.
Biological function summary
LMCD1 regulates gene expression by acting as a transcriptional co-regulator. It is not part of a large complex but interacts with other proteins to modulate cardiac and hepatic functions. By affecting transcription LMCD1 influences development and maintenance of specific tissue structures including heart muscle and liver tissues.
Pathways
LMCD1 plays a role in the regulation of the Wnt signaling pathway vital for cardiac and hepatic development. It interacts with beta-catenin a central protein in this pathway impacting cell growth and differentiation. LMCD1 also has connections to the TGF-beta signaling pathway where it associates with Smad proteins that mediate cellular responses.
LMCD1 links to cardiac hypertrophy and hepatocellular carcinoma. In cardiac hypertrophy it interacts with GATA4 a transcription factor involved in heart muscle growth. In hepatocellular carcinoma changes in LMCD1 expression can disrupt normal cell proliferation by altering TGF-beta signaling affecting several downstream targets including SMAD proteins.