Abcam, ab121804, Anti-ZNF704 antibody

Size: 100µL
Rabbit Polyclonal ZNF704 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF704 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF704 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q6ZNC4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF704 also known as Zinc Finger Protein 704 is a transcription factor that influences gene expression. It contains zinc finger domains enabling it to bind DNA and regulate transcription. The protein exhibits a mass of approximately 43 kDa. Expression of ZNF704 occurs in various tissues but it is more prominent in the brain and reproductive organs. This spatial distribution suggests a role in neural and reproductive functions.
Biological function summary
The functions of ZNF704 link tightly to transcriptional regulation and cellular proliferation. It commonly functions as part of a chromatin-remodeling complex modifying the structure of chromatin to either promote or inhibit gene transcription. ZNF704 interactions often compromise critical control of the cell cycle and affect genes responsible for cell division and differentiation. Through these interactions ZNF704 has an impact on development and physiological processes.
Pathways
The activity of ZNF704 influences key signaling pathways including the Wnt and Notch pathways. Both pathways are central to processes like embryogenesis and cell fate determination. ZNF704 also exhibits interactions with proteins such as β-catenin in the Wnt pathway and NICD in the Notch pathway. These interactions suggest that ZNF704 plays a role in modulating the transcriptional outputs of these signaling cascades. Through this modulation ZNF704 can affect cellular functions and developmental processes.
Research connects ZNF704 to certain cancers and neurodevelopmental disorders. In cancer ZNF704 overexpression links to breast and ovarian cancers. ZNF704 interacts with proteins like p53 which is important for tumor suppression suggesting a potential role in tumor progression when dysregulated. Additionally alterations in ZNF704 expression correlate with neurodevelopmental disorders potentially due to its role in brain development and its interaction with neurodevelopmental proteins. These associations highlight the importance of understanding ZNF704 for insights into these diseases.