Abcam, ab121844, Anti-DPYS antibody

Size: 100µL
Rabbit Polyclonal DPYS antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DPYS aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DPYS aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q14117

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DPYS also known as dihydropyrimidinase is an enzyme involved in the breakdown of pyrimidines specifically converting dihydropyrimidines to N-carbamyl-B-alanine. The mass of DPYS is approximately 56 kDa. This enzyme is present in various tissues most notably in the liver and kidney. DPYS plays a role in the catabolic pathway of nucleic acids facilitating the reuse and recycling of building blocks required for nucleic acid synthesis.
Biological function summary
DPYS functions as part of the larger pyrimidine degradation pathway. It does not act in isolation but may associate with other enzymes responsible for subsequent steps in this pathway. Pyrimidine metabolism is essential for maintaining the nucleotide pool balance in cells aiding cellular replication and repair processes. DPYS ensures efficient conversion of potentially harmful intermediates into products that cells can either reuse or excrete safely.
Pathways
The activity of DPYS is integrated into the pyrimidine catabolic pathway which intersects with the urea cycle. This enzyme works alongside others such as dihydropyrimidine dehydrogenase (DPYD) to facilitate pyrimidine degradation. The interactions between DPYS and DPYD are critical as they control the levels of pyrimidine metabolites in the cell preventing accumulation that could cause cellular stress or damage.
Mutations in the DPYS gene correlate with the rare metabolic disorder called dihydropyrimidinuria. This condition manifests due to the inefficient breakdown of pyrimidines leading to excessive urinary excretion of dihydropyrimidines. Furthermore impaired DPYS activity may have implications in drug metabolism particularly fluoropyrimidine-based cancer therapies as reduced activity can lead to toxicity. DPYD also connects to these conditions through its role in pyrimidine degradation highlighting the interdependence of these enzymes in both regular metabolic function and disease states.