Abcam, ab121887, Anti-Tenascin-N antibody

Size: 100µL
Rabbit Polyclonal Tenascin-N antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TNN aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TNN aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9UQP3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tenascin-N also known as TNN or Tenascin-W is a glycoprotein within the tenascin family which includes Tenascin-C Tenascin-X and Tenascin-R. It weighs approximately 150 kDa. Tenascin-N is expressed in specific tissues including the central nervous system muscle tissues and various regions of the developing skeleton. It mainly localizes in the extracellular matrix where it interacts with components like fibronectin and integrins to facilitate cellular interactions.
Biological function summary
The protein plays important roles in cell adhesion migration and proliferation. It does not typically form part of a larger complex but acts independently to modulate cellular environments. In the context of musculoskeletal development and neural tissue architecture Tenascin-N creates a scaffold that supports cell organization and tissue rigidity. It adjusts cell behavior through binding interactions impacting essential developmental signaling.
Pathways
Tenascin-N influences specific signaling cascades pertinent to skeletal and nervous system development. It interacts with the Wnt signaling pathway aligning with proteins such as β-catenin. Furthermore it modulates the PI3K/AKT pathway influencing cell survival and proliferation. These interactions reflect Tenascin-N's role in development and response to cellular stress.
Tenascin-N associates with gliomas and osteosarcomas. In glial tumors its expression levels correlate with tumor progression possibly interacting with integrin-linked proteins. Osteosarcomas display altered Tenascin-N patterns indicating a connection to abnormal osteoblast function. In these contexts Tenascin-N works alongside other tenascin family members fostering environments conducive to malignant growth and altered cellular mechanics.