Abcam, ab121890, Anti-SPINK2 antibody

Size: 100µL
Rabbit Polyclonal SPINK2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SPINK2 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SPINK2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P20155

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SPINK2 also known as Serine Protease Inhibitor Kazal-type 2 functions mechanically as a serine protease inhibitor that regulates proteolytic processes. The molecular mass of SPINK2 is approximately 8.5 kDa. It has expression in a variety of tissues most prominently in the testes but also in other organs such as the ovary and kidney. SPINK2 has a role in the defense against protease enzyme reactions that can lead to tissue damage by inhibiting proteolytic activities.
Biological function summary
SPINK2 plays an important role in maintaining tissue integrity by restricting excessive protease activity. This can be critical in tissues that undergo regular structural changes. SPINK2 does not associate with a particular complex but impacts several biological processes by modulating the activity of enzymes it inhibits. This function highlights its role in cellular protection and maintenance especially within reproductive tissues where dynamic protein degradation and synthesis are consistent.
Pathways
This protease inhibitor takes part in essential regulatory pathways such as the coagulation cascade and the management of protease activity in various tissues. Its activity influences pathways involving serine proteases such as the kallikrein system. Directly related proteins through these pathways include proteases like kallikreins which SPINK2 inhibits to modulate physiologic balance within the reproductive and other organ systems.
SPINK2 has links to conditions such as male infertility where abnormal protease activity can disrupt normal spermatogenesis. It also associates with certain cancer types like testicular cancer where protease regulation goes awry. In these contexts SPINK2 interacts with other proteins like the cancer-promoting oncoproteins and proteases that drive tumor progression and metastasis indicating a potential avenue for therapeutic interventions targeting abnormal SPINK2 function.