Abcam, ab121910, Anti-MTERFD2 antibody

Size: 100µL
Rabbit Polyclonal MTERFD2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MTERF4 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MTERF4 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q7Z6M4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MTERFD2 also known as mitochondrial transcription termination factor D2 is a human protein with a molecular mass of approximately 43 kDa. It is expressed in mitochondria specifically within the inner mitochondrial membrane. The protein plays a mechanical role in the transcription of mitochondrial DNA by influencing the termination process which helps regulate mitochondrial gene expression. MTERFD2 has a unique function compared to other MTERF family members due to its specific terminator sites.
Biological function summary
The role of MTERFD2 extends to the stabilization of mitochondrial DNA transcription processes. It is a part of the MTERF protein family which includes other transcription termination factors like MTERFD1 and MTERFD3. These proteins function together but MTERFD2 has a distinct activity in managing the balance and levels of various mitochondrial transcripts. This ensures proper mitochondrial function and energy production which are important for cell survival and metabolism.
Pathways
MTERFD2 is involved in the mitochondrial gene expression pathway and mitochondrial biogenesis. The protein assists in maintaining mitochondrial homeostasis which relates closely with other proteins like POLRMT the mitochondrial RNA polymerase. This interaction facilitates the transcriptional dynamics needed for efficient mitochondrial operation highlighting MTERFD2's necessary role in cellular energy pathways.
Research links MTERFD2 to metabolic disorders and neurodegenerative diseases. Alterations in MTERFD2 function can impair mitochondrial transcription and energy production contributing to conditions like mitochondrial myopathy. It also shows connections with proteins such as TFAM another mitochondrial transcription factor which affects similar mitochondrial functions. Understanding MTERFD2's role in these contexts is essential for developing therapeutic strategies for related diseases.