Abcam, ab121935, Anti-WDR47 antibody

Size: 100µL
Rabbit Polyclonal WDR47 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WDR47 aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human WDR47 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.O94967

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR47 also known as WD repeat domain 47 is a protein with a molecular weight of approximately 45 kDa. This protein features several WD40 repeats which are structural motifs often linked to protein-protein interactions. WDR47 is mainly expressed in the brain and in some other tissues. It shows high expression during brain development suggesting its involvement in this process. The mechanical role of WDR47 involves acting as a scaffold facilitating various molecular interactions necessary for cellular mechanisms.
Biological function summary
WDR47 is important for regulating processes such as cell migration and neuronal development. WDR47 is part of a multiprotein complex interacting with other key proteins that assist in coordinating cellular dynamics. These interactions help manage the assembly and breakdown of cytoskeletal elements which are vital to maintain cell shape and enable movement. In turn these processes influence neural growth and repair affecting the formation of neural circuits.
Pathways
WDR47 integrates into signaling networks that manage cellular morphology and signaling in neurons. It plays significant roles in pathways like the Wnt signaling pathway and the neuronal polarization process. Within these pathways WDR47 interacts with proteins such as Dishevelled (Dvl) and APC contributing to cellular communication processes essential for proper neuron alignment and pathway signaling. The involvement in these pathways highlights WDR47's role in establishing and maintaining cellular architecture and signal transmission.
Disruptions in WDR47 can relate to neurological conditions such as intellectual disability and developmental brain disorders. Altered expression or mutations of WDR47 have implications for these conditions often influencing other proteins like Dvl and other cytoskeletal components involved in neural signaling and structural maintenance. Understanding the exact role of WDR47 in these diseases can potentially reveal targeted approaches for therapeutic strategies.