Abcam, ab122009, Anti-AHDC1 antibody

Size: 100µL
Rabbit Polyclonal AHDC1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AHDC1 aa 1150-1300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AHDC1 aa 1150-1300. The exact immunogen used to generate this antibody is proprietary information.Q5TGY3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AHDC1 also known as AT hook DNA binding motif containing 1 is a nuclear protein with a molecular mass of approximately 160 kDa. This protein is expressed in various tissues throughout the body including the heart kidney and brain. AHDC1 functions in the nucleus where it is believed to influence DNA processes due to its DNA binding capability. Researchers continue to study the specific mechanical actions of AHDC1 but its presence in critical body tissues demonstrates its significance in cellular function.
Biological function summary
AHDC1 influences developmental processes by affecting gene expression. It forms part of a protein complex that interacts with nuclear chromatin which suggests a role in transcription regulation. AHDC1's interaction within the nucleus possibly affects the transcription of genes critical for cell growth and division. The ability to influence nuclear architecture hints towards AHDC1's involvement in orchestrating complex genetic networks.
Pathways
AHDC1 integrates into genetic and signaling pathways important for cellular development. It participates in pathways involving the regulation of gene expression and chromatin remodeling. Known associations exist between AHDC1 and factors involved in chromatin modification like histone-related proteins highlighting its role in gene expression control. AHDC1’s involvement in transcription may link to other proteins in these pathways facilitating the activation or repression of genes necessary for proper cell cycle progression.
AHDC1 has been linked to neurodevelopmental disorders including Xia-Gibbs syndrome. Aberrations in AHDC1 expression or function have implications in cognitive disabilities and developmental delays. These disruptions also connect it to proteins involved in neural development highlighting the cascading effects of its dysfunction. Continued research may reveal additional connections between AHDC1 dysfunction and other conditions broadening its impact on understanding genetic disorders.