Abcam, ab122024, Anti-SLC6A7 antibody

Size: 100µL
Rabbit Polyclonal SLC6A7 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC6A7 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC6A7 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q99884

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC6A7 also known as the Proton-dependent Amino Acid Transporter (PAT2) is a member of the solute carrier family 6. This transporter specifically facilitates the uptake of proline and other amino acids in cells working through a sodium-dependent mechanism. It has a molecular mass of approximately 76 kDa. SLC6A7 is predominantly expressed in the central nervous system with notable expression in the brain highlighting its role in neural processes.
Biological function summary
The transporter plays a significant role in neurotransmitter regulation and modulation. By controlling the levels of amino acids within neural tissues SLC6A7 contributes to neurotransmission and synaptic plasticity. This transporter functions as part of a broader amino acid transport system that maintains cellular homeostasis within neurons ensuring proper signaling and metabolic processes.
Pathways
This solute carrier is an important component of amino acid transport and metabolism pathways. It participates in the neurotransmitter cycle interacting closely with GABA and glutamate pathways which are critical for synaptic signaling in the brain. SLC6A7 shares functional relationships with closely related transporters such as SLC6A1 and SLC6A3 which also partake in neurotransmitter processes and transport mechanisms.
SLC6A7 is linked to neurological conditions such as epilepsy and schizophrenia. The dysregulation of amino acid transport mediated by this protein can disrupt neurotransmitter balance which may contribute to the pathophysiology of these disorders. In schizophrenia for example altered function of SLC6A7 can have downstream effects on proteins like glutamate receptors impacting neuronal activity and cognitive function.