Abcam, ab122164, Anti-KLHL17 antibody

Size: 100µL
Rabbit Polyclonal KLHL17 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KLHL17 aa 550 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KLHL17 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6TDP4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KLHL17 also known as Kelch-like protein 17 has a molecular mass of approximately 68 kDa. This protein belongs to the Kelch-like family characterized by the presence of a BTB/POZ and kelch domains. KLHL17 functions as an adaptor protein linking specific substrate proteins to the ubiquitin-proteasome system for targeted degradation. Expression of KLHL17 occurs mainly in the central nervous system.
Biological function summary
KLHL17 influences neuronal function and development. It forms part of an E3 ubiquitin ligase complex associating with Cullin 3 to facilitate protein ubiquitination. This complex plays a role in synaptic activity by regulating the levels of proteins critical for neuronal signaling. In the brain KLHL17 contributes to the fine-tuning of signaling pathways affecting cognition and memory.
Pathways
KLHL17 integrates into protein degradation and neurodevelopmental signaling pathways. It interacts with components of the ubiquitination pathway primarily linked with Cullin 3. By mediating substrate protein ubiquitination KLHL17 indirectly affects pathways like the Wnt signaling pathway essential for neuronal development. It also cooperates with proteins such as beta-catenin which participates in a wide range of cellular processes.
KLHL17 associates with neurodevelopmental and neurodegenerative diseases. Alterations in KLHL17 function may contribute to conditions such as Alzheimer's disease. Through its role in protein turnover and signaling modulation KLHL17 interacts with other proteins like amyloid precursor protein (APP) which may influence the pathological cascades associated with such disorders.