Abcam, ab122182, Anti-FOXRED2 antibody

Size: 100µL
Rabbit Polyclonal FOXRED2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXRED2 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FOXRED2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q8IWF2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXRED2 also known as FAD-dependent oxidoreductase domain-containing protein 2 is an enzyme with a molecular weight of about 67 kDa. This target is found in various tissues with a high expression in the pancreas and brain. FOXRED2 is part of the broader group of oxidoreductases essential for catalyzing redox reactions. These reactions are important for maintaining proper cellular function by balancing oxidation-reduction processes.
Biological function summary
FOXRED2 assists in mitochondrial maintenance and energy production. It participates in protein folding within the endoplasmic reticulum (ER) and takes part in the mitochondrial oxidative phosphorylation system. This protein may function as part of a complex network that helps ensure proper protein structure and function inside cells which is critical for cellular health and activity. Enhanced activity in energy-demanding tissues emphasizes its role in cellular metabolism.
Pathways
FOXRED2 plays key roles in mitochondrial energy metabolism and ER-associated degradation (ERAD) pathways. In these networks it interacts with chaperone proteins like BiP/GRP78 which help with protein folding and avoiding protein aggregation. The involvement of FOXRED2 in the oxidative phosphorylation pathway links it with proteins such as cytochrome c oxidase which ultimately supports ATP production the main energy currency of the cell.
FOXRED2 has been associated with neurodegenerative diseases such as Parkinson's disease due to its role in energy metabolism and mitochondrial function. Additionally there is a connection to certain pancreatic disorders including exocrine pancreatic insufficiency. Its interactions with other proteins like PINK1 a well-known contributor to mitochondrial quality control highlight potential mechanisms where FOXRED2 dysfunction may contribute to these disorders.