Abcam, ab122239, Anti-Aftiphilin antibody

Size: 100µL
Rabbit Polyclonal Aftiphilin antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AFTPH aa 250-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AFTPH aa 250-350. The exact immunogen used to generate this antibody is proprietary information.Q6ULP2

Product details:
ab122239 is mono-specific.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Aftiphilin is a protein involved in the formation of vesicles and transport processes in the cell. Known alternatively as AFTPH it weighs around 80 kDa. Researchers identify its expression mainly in various tissues especially in the brain and some epithelial cells. Its primary role is associated with its function in clathrin-mediated endocytosis a process critical for the internalization of molecules at the cellular membrane.
Biological function summary
Aftiphilin operates by interacting with other proteins to facilitate vesicle trafficking. It is a component of a larger complex that includes p200 and epsinR where it plays a role in stabilizing clathrin-coated vesicles. These interactions suggest its importance in maintaining cellular transport dynamics and in various membrane-related processes. Its precise functioning influences several biological systems by ensuring that cellular materials are properly transported and sorted.
Pathways
Aftiphilin participates in the clathrin-mediated endocytosis pathway and the Golgi-endosomal transport pathway. Within these pathways aftiphilin interacts with clathrin and AP-1 both of which assist in ensuring that molecular cargo is accurately directed and delivered within the cell. These pathways are essential for maintaining cellular homeostasis and are key to the efficient recycling and redistribution of membrane components.
Altered function or expression of aftiphilin links to certain neurological conditions and cancer. For instance dysregulation in aftiphilin activity associates with Alzheimer’s disease where it may affect protein trafficking and clearance leading to toxic accumulation. Similarly aftiphilin can interact with cancer-related proteins like EGFR potentially affecting tumor progression through misregulated signaling and endocytosis processes. Understanding these connections highlights aftiphilin's role in both health and disease offering potential paths for therapeutic interventions.