Abcam, ab122250, Anti-Golgin-245 antibody

Size: 100µL
Rabbit Polyclonal Golgin-245 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GOLGA4 aa 1450-1600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GOLGA4 aa 1450-1600. The exact immunogen used to generate this antibody is proprietary information.Q13439

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Golgin-245 also known as GM130L or Golgin subfamily A member 4 is an important component in membrane trafficking processes involving the Golgi apparatus. This protein has an approximate mass of 245 kDa and is expressed mainly in the perinuclear region of mammalian cells. It plays a role in maintaining the structural integrity of the Golgi by facilitating vesicle tethering which is important for the movement of proteins and lipids through the secretory pathway.
Biological function summary
Golgin-245 interacts with other proteins to ensure proper Golgi function and organization. It is part of a larger protein complex that participates in vesicle docking and fusion events. By anchoring transport vesicles Golgin-245 ensures that cargo is accurately delivered supporting cell-secretory processes. This interaction enables Golgin-245 to contribute to the maintenance of efficient intracellular communication and protein processing ultimately impacting various physiological processes.
Pathways
Golgin-245 plays a critical role in the secretory pathway. This pathway involves the transport of proteins from the endoplasmic reticulum through the Golgi apparatus to their final destinations. Golgin-245 works alongside proteins like Rab6 and Arf1 which regulate vesicle formation and movement. These proteins and Golgin-245 coordinate to ensure the smooth transit of vesicles highlighting Golgin-245's important function in maintaining cellular homeostasis.
Golgin-245 has been implicated in conditions like neurodegenerative diseases and certain types of cancer. Its function of mediating proper protein transport is linked with proteins such as β-amyloid precursor protein in Alzheimer's disease. Aberrations in Golgin-245's activity can lead to disruptions in protein trafficking which has been observed in neurodegeneration. Furthermore its altered expression is associated with cancer progression where improper protein distribution contributes to abnormal cell proliferation and tumor growth.