Abcam, ab122258, Anti-SGOL2 antibody

Size: 100µL
Rabbit Polyclonal SGOL2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SGO2 aa 200-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SGO2 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.Q562F6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SGOL2 also known as Shugoshin-like 2 is a protein that plays an important role in ensuring correct chromosome segregation during cell division. It has a molecular weight of approximately 126 kDa. SGOL2 is mainly expressed in tissues undergoing active cell division. The protein is mainly located in the centrosomes and kinetochores during mitosis where it helps to maintain the cohesion of sister chromatids until they are ready to separate.
Biological function summary
SGOL2 ensures proper mitotic progression by protecting the cohesin complex at centromeres during meiosis. It is an integral part of the chromosomal passenger complex which includes other key proteins like aurora B kinase and inner centromere protein (INCENP). This complex helps regulate chromosome alignment and segregation ensuring each daughter cell receives accurate complements of chromosomes.
Pathways
The cell cycle relies heavily on proteins securing chromatid cohesion like SGOL2. In the anaphase-promoting complex/cyclosome (APC/C) pathway SGOL2 works alongside proteins such as separase and securin. Its protective action on the cohesin complex ensures the orderly progression through the cell cycle and prevents premature sister chromatid separation.
Defective SGOL2 function links closely to errors in chromosome segregation contributing to conditions like aneuploidy and cancer. It has connections with other proteins involved in chromosomal stability such as separase. Understanding SGOL2's role in these disorders could lead to potential therapeutic targets for treating chromosomal instability syndromes a common feature in cancerous cells.