Abcam, ab122280, Anti-ADAT2 antibody

Size: 100µL
Rabbit Polyclonal ADAT2 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ADAT2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ADAT2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q7Z6V5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADAT2 also known as ADAT2 deaminase plays an important role in RNA editing by converting adenosines to inosines in tRNA molecules. This deaminase has a mass of roughly 50 kDa and is widely expressed in various tissues. Its presence is important for maintaining RNA stability and accurate coding which together plays pivotal part in protein synthesis.
Biological function summary
ADAT2 works as part of the ADAT complex that includes ADAT3. This complex specifically targets anticodon regions of tRNAs. The conversion of adenosine to inosine by ADAT2 changes the reading of certain codons allowing for proper interpretation of genetic code elements important for cell function and viability. ADAT2’s activity impacts the modification process essential for accurate protein translation.
Pathways
Four important mechanisms involve ADAT2 in RNA metabolic processes. It plays an integral role in the post-transcriptional modification of RNA particularly within the tRNA maturation pathway. This pathway collaborates with proteins such as ADAT3 and their interaction governs fidelity in transcribing genetic information into proteins. The editing by ADAT2 ensures that tRNA molecules can correctly interpret codons during translation.
Four recognized conditions involve faulty ADAT2 activity: one is neurodevelopmental disorders where genetic mutations affecting its function impact brain development. Another is some types of cancer where RNA editing disruptions play part in tumorigenic processes. These diseases can involve interactions with other proteins like ADAT3 that need for proper RNA editing balance. Understanding these interactions may help in developing therapeutic strategies targeting RNA editing mechanisms.