Abcam, ab122301, Anti-ZSWIM6 antibody

Size: 100µL
Rabbit Polyclonal ZSWIM6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZSWIM6 aa 600-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZSWIM6 aa 600-700. The exact immunogen used to generate this antibody is proprietary information.Q9HCJ5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZSWIM6 also known as Zinc Finger SWIM-type Containing 6 is a protein weighing approximately 117 kDa. This protein contains zinc finger motifs which facilitate its interaction with DNA or other proteins. Recognizing it by its SWIM domain one can find it highly expressed in the brain and other tissues suggesting a role in diverse cellular functions. Its distinct expression pattern indicates its involvement in specific cellular processes such as development and signaling within the nervous system.
Biological function summary
ZSWIM6 participates in developmental processes and possibly influences neuronal activity. As part of specific protein complexes it may interact with DNA and other regulatory proteins to mediate gene expression affecting cellular development and function. Its functionality in growth and neuron communities highlights its potential role in brain development and morphology.
Pathways
ZSWIM6 associates with pathways involved in neurodevelopment like the Wnt signaling pathway influencing cell growth differentiation and migration. It links with other proteins such as Dishevelled (DVL) involved in the Wnt pathway. Another related pathway is the mitogen-activated protein kinase (MAPK) pathway which also has a critical role in transmitting signals from receptors on the cell surface to the DNA in the nucleus affecting cellular responses.
ZSWIM6 has connections to neurological disorders such as autism spectrum disorders and intellectual disabilities. Its mutations or dysregulation can disrupt normal brain development and function. It also shows a relationship with proteins like SHANK3 which are implicated in synaptic function and disorders like autism. This association highlights its importance in maintaining neuronal connectivity and proper cognitive function.