Abcam, ab122342, Anti-SH3PXD2B antibody

Size: 100µL
Rabbit Polyclonal SH3PXD2B antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH3PXD2B aa 550-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SH3PXD2B aa 550-650. The exact immunogen used to generate this antibody is proprietary information.A1X283

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SH3PXD2B also known as TKS4 acts mechanically as an adaptor protein involved in the regulation of intracellular signaling. The protein has a molecular mass of approximately 99 kDa. It is ubiquitously expressed with particularly high levels observed in the brain lung and kidney. SH3PXD2B possesses an SH3 domain that allows it to bind to proteins rich in proline playing a significant role in cellular communication.
Biological function summary
SH3PXD2B contributes to the formation of invadopodia which are protrusive cellular structures that play an integral role in tissue invasion and matrix degradation. It is usually found as part of a complex that includes proteins like cortactin and N-WASP. SH3PXD2B's involvement in these processes makes it significant for cellular movement and remodeling of the extracellular matrix which are vital for various biological functions.
Pathways
SH3PXD2B interacts with the reactive oxygen species (ROS) signaling pathway and the actin cytoskeleton organization. It connects functionally with proteins such as Src kinase which plays an important role in actin dynamics. These interactions facilitate SH3PXD2B's role in promoting cellular motility and invasiveness linking it to pathways that affect cell migration and adhesion.
SH3PXD2B has associations with Frank-Ter Haar syndrome and cancer metastasis. Mutations in SH3PXD2B relate to the development of Frank-Ter Haar syndrome which affects skeletal and craniofacial development. In cancer SH3PXD2B's role in invadopodia formation contributes to the metastatic potential of tumor cells working alongside proteins like matrix metalloproteinases (MMPs) that degrade the extracellular matrix during metastasis.