Abcam, ab122351, Anti-STT3B antibody

Size: 100µL
Rabbit Polyclonal STT3B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STT3B aa 450-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STT3B aa 450-550. The exact immunogen used to generate this antibody is proprietary information.Q8TCJ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STT3B also known as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B is an integral component of the oligosaccharyltransferase complex. STT3B weighs approximately 84 kDa. It predominantly resides in the endoplasmic reticulum of eukaryotic cells. This protein facilitates the transfer of glycan chains to nascent proteins which is essential for proper protein folding and stability during glycosylation process.
Biological function summary
Oligosaccharide transfer processes necessitate the presence of STT3B which acts as a catalytic subunit. STT3B is vital in the post-translational modification process as it participates in co-translational and post-translational N-linked glycosylation. As part of the Sec61 complex it collaborates with other subunits such as STT3A to ensure complete glycosylation particularly for those sites missed by STT3A during initial protein synthesis.
Pathways
Protein glycosylation heavily relies on STT3B's function. It integrates within the N-glycan biosynthesis pathway influencing protein quality control and degradation pathways. Alongside proteins like STT3A and other components of the oligosaccharyltransferase complex it determines proper protein localization and stability. This pathway contributes to cellular processes linked with protein maturation and trafficking.
Defective function of STT3B impacts congenital disorders of glycosylation (CDGs). This protein's dysfunction interrupts normal glycosylation patterns leading to multisystemic issues. Its connection with proteins in the glycosylation pathway such as DDOST highlights its relevance in glycosylation-related ailments. Additionally alterations in STT3B may relate to certain cancer types where abnormal glycosylation can influence tumor progression and immune evasion.