Abcam, ab122352, Anti-SCC112 antibody

Size: 100µL
Rabbit Polyclonal SCC112 antibody. Suitable for IHC-P, ICC/IF, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDS5A aa 1250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PDS5A aa 1250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q29RF7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCC112 also known as LAP1B is a protein involved in cellular structure and function processes. It has a molecular weight of approximately 75 kDa. SCC112 is expressed in various tissues including liver kidney and muscle. The protein is localized mainly to the inner nuclear membrane where it plays roles in maintaining nuclear structure and function. This localization position allows SCC112 to interact with a range of other nuclear proteins showing its involvement in broader cellular processes.
Biological function summary
The role of SCC112 is linked to its ability to regulate nuclear architecture and chromatin organization. It is part of the nuclear lamina-associated polypeptide family and is involved in complex formations with proteins responsible for maintaining nuclear stability. SCC112 influences the dynamics of chromatin interactions which impacts gene expression. Through these complex formations SCC112 helps in organizing the nuclear architecture which has downstream effects on various cellular activities.
Pathways
SCC112 acts within the nuclear envelope dynamics and chromatin organization pathways. It closely interacts with lamin proteins such as LMNA and LMNB1 which are essential for nuclear stability. These interactions facilitate the cohesion of nuclear structures and are necessary for appropriate chromatin organization. The involvement of SCC112 in these pathways suggests a broad influence on cellular replication and gene regulation. The precise regulation of chromatin architecture by SCC112 plays a significant part in cellular division processes and the maintenance of cellular integrity.
SCC112 has been associated with muscular dystrophy and certain types of cancer. Alterations in SCC112 expression levels can impact the balance of nuclear stability contributing to diseases such as Emery-Dreifuss muscular dystrophy where LMNA mutations are prevalent. Also abnormalities in SCC112 have been noted in certain cancer types suggesting a possible role in tumor progression. The connection with these diseases highlights the significant influence of SCC112 on nuclear integrity and cellular health.