Abcam, ab122400, Anti-NEURL1B antibody

Size: 100µL
Rabbit Polyclonal NEURL1B antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NEURL1B aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NEURL1B aa 150-250. The exact immunogen used to generate this antibody is proprietary information.A8MQ27

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NEURL1B also known as neuralized E3 ubiquitin protein ligase 1B functions as an E3 ubiquitin ligase. This protein plays a role in tagging other proteins for degradation by the proteasome a process critical for maintaining cellular protein balance. NEURL1B has a molecular mass of approximately 70 kDa and is expressed markedly in neural tissues. It sometimes appears in other tissues but its expression is not as pronounced as in the nervous system.
Biological function summary
The protein acts as a regulator of the Notch signaling pathway which is essential for cell differentiation and proliferation. NEURL1B does not work alone; instead it often operates as a part of a larger protein complex that includes other ligases and substrates. Through this complex formation NEURL1B modifies signal transduction processes influencing various cellular functions.
Pathways
NEURL1B is tightly linked to the Notch signaling and Wnt/β-catenin pathways. These signaling routes are instrumental in development and oncogenesis. Within these pathways NEURL1B interacts with the Notch receptor and can inhibit its activity by promoting degradation. It also connects to other proteins such as DLL1 within the Notch pathway contributing to the modulation of cell fate decisions.
NEURL1B has associations with cancer and neurodevelopmental disorders. Dysregulation of the Notch signaling pathway where NEURL1B operates often correlates with tumorigenesis in specific cancers. Furthermore alterations in NEURL1B function are implicated in disorders like autism spectrum disorder potentially impacting neuronal connectivity and synapse formation. The protein's interaction with other signaling molecules such as the Notch receptor suggests its significance in these conditions.