Abcam, ab122421, Anti-TTC37 antibody

Size: 100µL
Rabbit Polyclonal TTC37 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SKIC3 aa 450-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SKIC3 aa 450-600. The exact immunogen used to generate this antibody is proprietary information.Q6PGP7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TTC37 protein also known as Tetratricopeptide Repeat Domain 37 is an important element in the cellular machinery of humans. It is a 1562 amino acid protein with a molecular weight of approximately 178 kDa. The TTC37 protein expresses mainly in the cytoplasm and is found in various tissues including the brain liver and gastrointestinal tract. It contains several tetratricopeptide repeat (TPR) motifs which are known to mediate protein-protein interactions indicating its role in cellular functions related to these processes.
Biological function summary
TTC37 is involved in managing processes essential for maintaining cellular homeostasis. It is part of the Ski complex which is involved in the regulation of RNA metabolism. TTC37's role in the Ski complex is to assist in the exosome-mediated RNA decay pathway contributing to the quality control of RNA within the cell. This regulation ensures the degradation of defective or surplus RNA molecules which is fundamental for correct gene expression and cellular function.
Pathways
The exosome-mediated decay pathway represents one of the key pathways in which TTC37 operates. Another significant pathway is the nonsense-mediated decay (NMD) pathway where TTC37 interacts with proteins like SKIV2L involved in eliminating aberrant mRNA transcripts. These pathways are vital for cellular regulation and preventing the buildup of faulty RNA that could disrupt normal cell function. By engaging with these pathways TTC37 helps preserve the balance of RNA within the cell ensuring efficient communication and processing essential for cell survival and adaptation.
TTC37 mutations have been associated with a rare genetic disease known as Trichohepatoenteric syndrome (THES). This condition affects multiple systems including the skin liver and intestines and is characterized by growth retardation and immunodeficiency. TTC37's relation to this syndrome highlights its importance in maintaining cellular and physiological health. Additionally proteins such as SKIV2L which work alongside TTC37 are similarly implicated in conditions with overlapping clinical features emphasizing the shared pathways and interactions within these disorders.