Abcam, ab122440, Anti-FAM13A antibody

Size: 100µL
Rabbit Polyclonal FAM13A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FAM13A aa 900-1000.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FAM13A aa 900-1000. The exact immunogen used to generate this antibody is proprietary information.O94988

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FAM13A protein also known as Family with Sequence Similarity 13 Member A has a mass of approximately 120 kDa. It plays a role in cellular signaling and mechanisms related to cytoskeletal dynamics. FAM13A is expressed in various tissues with high levels present in the lungs and to some extent in skeletal muscle and adrenal glands. The expression pattern indicates its broad functional roles influencing multiple physiological processes.
Biological function summary
FAM13A contributes to the regulation of cell migration and adhesion. It interacts with the actin cytoskeleton and influences cellular morphology and movement. FAM13A is known to be part of a complex involved in Rho GTPase signaling which regulates actin dynamics and influences cell shape and movement. This involvement highlights its significant role in cellular communication and structural organization.
Pathways
FAM13A has a connection to the Wnt signaling and Rho GTPase pathways. These pathways are key in cellular differentiation and cytoskeletal rearrangements. FAM13A interacts with proteins like DVL1 within the Wnt pathway and RhoA in the Rho GTPase signaling pathway. Its role in these pathways suggests its involvement in transducing signals that affect cell fate and structure.
FAM13A has associations with chronic obstructive pulmonary disease (COPD) and lung cancer. In COPD altered FAM13A expression affects lung function possibly through its role in cytoskeletal regulation and cell migration. It has been linked with proteins involved in inflammation and cell adhesion. In the context of lung cancer aberrant FAM13A expression might contribute to tumor progression by influencing pathways related to cell movement and invasion. Understanding its interactions and functions in these conditions could lead to new insights in disease treatment and prevention.