Abcam, ab122475, Anti-FRMD4A antibody

Size: 100µL
Rabbit Polyclonal FRMD4A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FRMD4A aa 900-1000.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FRMD4A aa 900-1000. The exact immunogen used to generate this antibody is proprietary information.Q9P2Q2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FRMD4A also known as FERM Domain Containing 4A is a protein with an important role in cellular signaling. It has a molecular mass of approximately 80 kDa. This protein is expressed in various human tissues with strong presence in the brain. As a part of the FERM domain-containing protein family FRMD4A participates in the organization of the cell cortex and binds to several partners facilitating signal transduction within cells.
Biological function summary
FRMD4A influences several intracellular mechanisms. It associates with a protein complex involved in cellular adhesion and junctions. This protein supports the maintenance of cell polarity and potentially regulates the cytoskeleton. The interaction of FRMD4A with cytohesin proteins notably showcases its potential role in modulating cellular activities like migration and morphogenesis.
Pathways
FRMD4A plays an active role in the Epithelial Growth Factor Receptor (EGFR) signaling pathway and cell adhesion pathways. It frequently interacts with cytohesin-1 linking it to critical intracellular signaling processes. These interactions suggest that FRMD4A contributes to the regulation of signaling pathways that coordinate cell growth and structural organization.
FRMD4A associates with neurological conditions like schizophrenia and autism spectrum disorders. Researchers have identified potential links between FRMD4A and disease through its interaction with proteins such as DISC1 a well-known genetic risk factor for psychiatric illnesses. These connections highlight FRMD4A as a possible target for therapeutic research in neurodevelopmental and neuropsychiatric conditions.