Abcam, ab122480, Anti-SLF2 antibody

Size: 100µL
Rabbit Polyclonal SLF2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLF2 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLF2 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q8IX21

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLF2 also known as Smc5-Smc6 complex localization factor 2 functions mechanically as an important player in DNA repair processes. It weighs approximately 180 kDa and displays a ubiquitous expression pattern across various tissues in the body. SLF2 operates by facilitating the proper localization of the Smc5-Smc6 complex to sites of DNA double-strand breaks which is essential for maintaining genomic stability.
Biological function summary
The protein SLF2 contributes to the DNA damage response by interacting with other molecular components to modulate DNA repair pathways. It integrates into the Smc5-Smc6 complex which plays a role in homologous recombination repair. This interaction assists cells in efficiently repairing DNA damages and supports cell cycle progression further influencing cellular responses to DNA damage.
Pathways
SLF2 takes part in cellular mechanisms that control the DNA damage response and repair pathways. It directly associates with the DNA repair pathway involving major players like the ATM and ATR protein kinases which sense DNA damage and initiate repair signals. This connection highlights SLF2's involvement in the proper activation of downstream signaling cascades necessary for resolving DNA lesions effectively.
SLF2's role in maintaining genomic stability links it to certain conditions like cancer where DNA repair processes often malfunction. Deficiencies or mutations in SLF2 can disrupt its interaction with counterparts such as the Smc5-Smc6 complex contributing to chromosomal instability seen in cancerous cells. Additionally disorders like Fanconi anemia a genetic instability disorder may correspond with aberrant functioning of SLF2 and its complex interactions.