Abcam, ab122519, Anti-C11orf80 antibody

Size: 100µL
Rabbit Polyclonal C11orf80 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TOP6BL aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TOP6BL aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q8N6T0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C11orf80 also known as PAxp is a protein that has important mechanical roles within the cell. The protein has a mass of approximately 50 kDa. C11orf80 is expressed widely in various tissues but shows higher expression levels in testis and skeletal muscles. The protein performs mechanical tasks that involve interactions with other cellular components and aids in maintaining cellular structure integrity.
Biological function summary
C11orf80 operates as part of a larger protein complex that engages in chromatin modification. The protein plays roles in regulating gene expression by helping modify how chromatin is structured affecting how genes are accessed for transcription. Through these alteration processes C11orf80 impacts cellular processes like growth and differentiation playing a significant function in maintaining normal cellular activities.
Pathways
C11orf80 contributes to essential cellular pathways including the chromatin remodeling pathway and the gene regulation pathway. It interacts with proteins such as BRG1 and BAF which are part of the Swi/Snf family to influence chromatin remodeling. These interactions help dictate how certain genes are activated or suppressed in response to cellular signals ensuring proper cellular function and response to physiological changes.
C11orf80 has connections to two primary diseases: cancer and muscular dystrophy. Abnormal expression or function of C11orf80 can disrupt chromatin modification leading to uncontrolled cell growth in several cancers including testicular cancer. In muscular dystrophy changes in C11orf80's function may affect muscle integrity contributing to disease progression. In both conditions its interactions with proteins like BRG1 and other chromatin remodelers highlight its significant role in disease mechanisms.