Abcam, ab122566, Anti-FAM107B antibody

Size: 100µL
Rabbit Polyclonal FAM107B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FAM107B aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FAM107B aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H098

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAM107B also known as FLJ22026 or neuron navigator 3-like protein functions mechanically through interaction with other cellular proteins. This protein has an approximate molecular mass of 14 kilodaltons. It expresses mainly in neuronal tissues but also appears in other cell types at lower levels. Its pattern of expression suggests a role in cell-specific functions possibly linked to its mechanical properties.
Biological function summary
The protein FAM107B contributes to maintaining cellular processes in the nervous system. Although not part of a larger complex it seems to support cellular responses to stress and repair mechanisms. Its functions might involve regulation of cellular growth and development. The presence in neural tissues points to a potential role in neural differentiation or maintenance.
Pathways
FAM107B plays an important role within cellular stress response mechanisms particularly in neural tissues. It associates with pathways related to the MAPK signaling pathway impacting cellular responses to extracellular signals. Additionally it has interactions with proteins like MEK and ERK which are important in transmitting signals from receptors on the cell surface to DNA in the nucleus.
FAM107B has connections to neurological disorders and cancer. Aberrant expression patterns have been observed in certain types of brain tumors suggesting a link between FAM107B's expression levels and tumorigenesis. Alterations of this protein might also relate to neurodegenerative diseases where misregulation of its associated pathways could affect neuronal survival. Interactions with proteins like APC and b-catenin through these diseases add further significance to its functional importance.