Abcam, ab122570, Anti-RCCD1 antibody

Size: 100µL
Rabbit Polyclonal RCCD1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RCCD1 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RCCD1 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.A6NED2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle, Store undiluted

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RCCD1 also known as RCG1 or RCG1A is a pivotal protein involved in regulating various cellular processes. It weighs approximately 28 kDa and primarily localizes in the nucleus. RCCD1 expression mainly occurs in tissues such as the brain and testes suggesting its importance in these specific sites. The protein interacts with other cellular components to carry out its functions effectively particularly playing a role in cellular division and growth regulation.
Biological function summary
RCCD1 integrates into the chromatin remodeling complex acting as an important modulator of transcriptional regulation. It serves to influence gene expression by modifying chromatin structure which impacts DNA accessibility. By participating in such complexes RCCD1 enables cellular adaptation to different growth conditions and stress responses. This protein ensures proper function and regulation of genes essential for cell survival and proliferation.
Pathways
RCCD1 contributes to the Wnt signaling pathway which heavily relies on interaction with the beta-catenin protein. The involvement in Wnt signaling indicates RCCD1's role in guiding cell fate decisions influencing processes like cell growth and differentiation. In addition RCCD1 aligns with the Notch signaling pathway associating with proteins such as Notch1 to regulate lateral inhibition and boundary formation during development.
RCCD1 exhibits connections with certain cancers notably colorectal cancer. The abnormal regulation of RCCD1 affects the Wnt signaling pathway often leading to uncontrolled cell proliferation related to tumorigenesis. RCCD1 also links with neurological disorders where its dysregulation impacts brain development and function possibly associating with proteins such as APP in Alzheimer's disease. These associations highlight the significant relevance of RCCD1 in disease progression and pathological outcomes.