Abcam, ab122626, Anti-C12orf34 antibody

Size: 100µL
Rabbit Polyclonal C12orf34 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FAM222A aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FAM222A aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q5U5X8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C12orf34 also known as chromosome 12 open reading frame 34 is a protein coding gene with a molecular mass of approximately 53 kDa. The protein expression of C12orf34 shows tissue-specific patterns prominently in the brain skeletal muscle and liver. This suggests its involvement in performing essential functions in these particular tissues. Notably it exhibits a unique sequence composition which may result in specific signaling or structural roles though precise mechanical actions remain under investigation.
Biological function summary
This protein appears to function as part of a larger protein complex indicating a collaborative role in intracellular processes. C12orf34 has been implicated in the regulation of signaling pathways that affect cellular growth and metabolism suggesting its importance in maintaining cellular homeostasis. Its activity may influence gene expression and protein synthesis connecting it to broader cellular functions within those systems where it is expressed.
Pathways
This protein acts within tightly regulated metabolic and signaling processes. It is associated with key pathways such as the PI3K-Akt pathway which is critical for regulating cell survival and growth. Through this pathway C12orf34 interacts with other proteins like mTOR a central regulator of cell metabolism. By participating in these pathways C12orf34 helps integrate external signals with cellular responses linking environmental cues with cellular growth and energy balance.
Researchers associate C12orf34 with conditions such as muscular dystrophy and neurodegenerative diseases. Its connection to these disorders suggests that mutations or dysregulation in C12orf34 or its associated pathways can disrupt normal cellular functions. Additionally the interaction of C12orf34 with proteins related to neurological health such as those in the Akt signaling pathway further supports its potential role in the onset or progression of these conditions. Understanding these links may offer insights into novel therapeutic strategies for related diseases.