Abcam, ab122685, Anti-RMI2 antibody

Size: 100µL
Rabbit Polyclonal RMI2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RMI2 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RMI2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96E14

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RMI2 also known as RecQ Mediated Genome Instability 2 or BLAP75 is a protein involved in maintaining genome stability. This protein is important in the DNA repair processes and has a molecular weight of about 60 kDa. RMI2 is mainly expressed in tissues with high proliferative rates including testis and bone marrow. Its expression is not limited to these tissues indicating a broader role in cellular activity.
Biological function summary
This protein works in coordination with other components for efficient DNA repair. RMI2 is a part of the BTR complex which includes BLM helicase topoisomerase IIIα and RMI1. Within this complex RMI2 acts to stabilize the structure and enhance the function of the helicase and topoisomerase activities. Its role ensures proper resolution of DNA structures during replication and repair preventing genomic instability and preserving cell integrity.
Pathways
RMI2 contributes to the homologous recombination and DNA damage response pathways. In these pathways it interacts with proteins such as BLM and RMI1. Together they play an important role in the accurate separation of homologous chromosomes and repair of double-strand breaks which are essential for genome maintenance and cell survival. RMI2 enhances the BTR complex's ability to manage replication stress and prevent inappropriate recombination events.
RMI2 has been linked to certain cancer types including leukemia and colon cancer. In these diseases dysregulated expression or mutations of RMI2 can influence the stability of the genome contributing to tumorous growth. Additionally the interactions between RMI2 and BLM are significant as mutations in BLM can lead to Bloom syndrome characterized by genomic instability and cancer predisposition. Understanding these interactions is important for potential therapeutic targets in cancer treatments.