Abcam, ab122692, Anti-TRAPPC8 antibody

Size: 100µL
Rabbit Polyclonal TRAPPC8 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRAPPC8 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TRAPPC8 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q9Y2L5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRAPPC8 also known as Trafficking Protein Particle Complex 8 is a component of a larger multi-subunit complex involved in intracellular trafficking. The molecular weight of TRAPPC8 is approximately 148 kDa. This protein is ubiquitously expressed with higher levels observed in tissues such as the brain and liver. TRAPPC8 assists as a tethering component that facilitates vesicle docking and fusion events which are critical for proper cellular trafficking.
Biological function summary
The TRAPPC8 protein operates as part of the TRAPP complex which is important for membrane trafficking processes. This complex acts as a guanine nucleotide exchange factor (GEF) for small GTPases like the Rab proteins which are master regulators of vesicle transport. Through its action TRAPPC8 helps maintain efficient protein transportation sorting and distribution across cellular compartments. It's fundamental for processes such as autophagy and organelle biogenesis highlighting its multifaceted role in maintaining cellular homeostasis.
Pathways
TRAPPC8 integrates into the cellular machinery by participating in the vesicular transport pathway and autophagic processes. Within these pathways its interaction with the TRAPP complex influences the activation of Rab GTPases important for the regulation of vesicle budding and fusion. The protein plays an important role in the coordination with other pivotal proteins such as Sec23 which is also involved in vesicle formation and transport.
TRAPPC8 has a link to genetic disorders such as hereditary spastic paraplegia (HSP) a condition affecting motor functions due to a failure in axonal transport. The protein’s dysfunction can also have implications in certain neurodegenerative diseases where disrupted transport processes play a role in disease pathogenesis. Furthermore TRAPPC8 has a connection with other proteins like SPG11 which is also implicated in hereditary spastic paraplegia highlighting a network of functional interactions that could be targeted for therapeutic strategies.